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【目的】探讨斑蝥酸在人乳头瘤病毒（HPV）感染宫颈癌患者调强放疗联合后装治疗中的应用价值。【方法】将68例 HPV 感染宫颈癌患者随机分为两组，每组34例，对照组患者采用调强放疗＋腔内后装治疗，观察组在对照组基础上加用去甲斑蝥酸钠，比较两组的治疗效果及放疗毒性反应情况。【结果】观察组治疗1周、1个月、3个月的 KPS 评分分别为（86．82±11．25）分、（89．22±10．24）分、（91．24±10．69）分，明显高于对照组（83．14±10．27）分、（82．91±9．87）分、（82．04±13．56）分，其差异有统计学意义（P ＜0．05）；观察组的临床有效率为94．12％（32／34），明显高于对照组73．53％（25／34），其差异有统计学意义（P ＜0．05）；观察组的3年生存率、5年生存率分别为76．67％、53．85％，与对照组（75．86％、53．85％）比较差异无统计学意义（P ＞0．05）；观察组患者的放射性肠炎、放射性膀胱炎、血红蛋白减少、白细胞减少、粒细胞减少、血小板减少发生率分别为55．88％、14．71％、26．47％、64．71％、38．24％、26．47％，均明显低于对照组（P ＜0．05），且观察组的不良反应程度也显著低于对照组（P ＜0．05）。【结论】HPV 感染宫颈癌患者在进行调强放射治疗时，应用斑蝥酸能有效提高治疗效果，同时减轻放疗不良反应，值得临床推广应用。“,”Objective]To study the clinical application value of cantharidin in intensity‐modulated radiotherapy com‐bined with after‐loading‐brachy therapy in patients of human papillomavirus (HPV) infection with cervical cancer .[Meth‐ods]Sixty‐eight patients with cervical cancer HPV infection were randomly divided into two groups ( n = 34) .Patients in the control group were treated with intensity modulated radiation therapy plus brachytherapy ,the observation group , based on the control group ,was treated with Sodium Demethylcantharidate .The treatment effect and the radiation toxicity reaction of the two groups were compared .[Results]KPS scores (86 .82 ± 11 .25) ,(89 .22 ± 10 .24) ,(91 .24 ± 10 .69)% for 1 week ,1 month and 3 months of the observation group were significantly higher respectively than those of the control group (83 .14 ± 10 .27) ,(82 .91 ± 9 .87) ,(82 .04 ± 13 .56) ,the difference was statistically significant ( P < 0 .05) ;The clinical effective rate of the observation group was 94 .12% (32/34) ,which was significantly higher than that of control group (25/34) ,and the difference was statistically significant ( P 0 .05) ;in the observation group ,the incidence rates of radiation enteritis , radiation cystitis ,hemoglobin reduction ,white blood cell reduction ,granulocyte reduction and thrombocytopenia were 55 .88% ,14 .71% ,26 .47% ,64 .71% ,38 .24% ,26 .47% respectively ,all of them were significantly lower than those of the control group (P < 0 .05) ,and the adverse reaction degree of the observation group was significantly lower than that of the control group ( P < 0 .05) .[Conclusion]In IMRT for patients of HPV infection with cervical cancer ,application of cantharidin can effectively improve the treatment effect and reduce the adverse effects of radiotherapy .It is worthy of clini‐cal application .