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用抗增殖细胞核抗原（PCNA）单克隆抗体，采用免疫组化ABC法检测了30例良性前列腺增生（BPH）和前列腺癌（PC）五蜡标本中PCNA的表达。结果表明PCNA阳性细胞百分率：BPH组为27．514．2％，PC组为49二6I8．9％，其中伴NE分化PC组为57．015．3％，不伴NE分化PC组为45．217．9％。结果显示伴NE分化PC组PCNA阳性细胞百分率明显高于BPH组（P＜0．05）。在14例PC存活者中，PCNA阳性细胞百分率低者的存活时间长于百分率高者。可见PCNA可能将成为PC患者内分泌治疗预后的重要指标。
The expression of PCNA in five specimens of benign prostatic hyperplasia (BPH) and prostatic carcinoma (PC) was detected by immunohistochemical ABC method using anti-proliferating cell nuclear antigen (PCNA) monoclonal antibody. The results showed that the percentage of PCNA positive cells was 27.514.2% in BPH group and 49% 61.89% in PC group, with 57.015.3% in PC group with NE and 45 in PC group without NE. 217.9%. The results showed that the percentage of PCNA positive cells in PC group with NE differentiation was significantly higher than that in BPH group (P <0.05). Of the 14 PC-survivors, those with a lower percentage of PCNA-positive cells lived longer than those with a higher percentage. PCNA may be seen as an important indicator of the prognosis of PC patients with endocrine therapy.