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目的:观察头孢拉定联合清胃汤对牙周病患者血清TNF-α及临床疗效的影响。方法:选择2016年1月至2016年3月在我院接受治疗的120例牙周病患者,根据给予患者不同治疗方法分为观察组和对照组,对照组用头孢拉定进行治疗,观察组则联合清胃汤进行治疗,均治疗2周,观察其治疗后的疗效以及对血清TNF-α的影响。结果:治疗后,观察组总有效率为95.0%,明显高于对照组(83.3%),两组比较差异具体统计学意义(P<0.05);治疗后,观察组血清TNF-α水平为(6.97±1.54)ng/L,明显低于对照组(7.58±1.59)ng/L,两组比较差异显著(P<0.05);观察组牙龈指数、牙龈沟出血指数、菌斑指数以及探针深度均明显低于对照组(P<0.05)。两组均发生了一些并发症,观察组发生率明显低于对照组(P<0.05)。结论:使用头孢拉定联合清胃汤治疗牙周病患者,能够明显降低血清TNF-α水平,其临床疗效显著,并能够降低并发症发生率,安全性较好。
Objective: To observe the effect of cefradine and Qingwei Decoction on serum TNF-α in patients with periodontal disease and its clinical effect. Methods: One hundred and twenty patients with periodontal disease who were treated in our hospital from January 2016 to March 2016 were divided into observation group and control group according to the different treatment methods given to patients. The control group was treated with cefradine, and the observation group was united Qingwei soup for treatment, were treated for 2 weeks to observe the therapeutic effect and the impact of serum TNF-α. Results: After treatment, the total effective rate in the observation group was 95.0%, which was significantly higher than that in the control group (83.3%), the difference between the two groups was statistically significant (P <0.05); After treatment, the level of serum TNF- 6.97 ± 1.54 ng / L, which was significantly lower than that of the control group (7.58 ± 1.59 ng / L, P <0.05). The gingival index, gingival sulcus bleeding index, plaque index and probe depth Were significantly lower than the control group (P <0.05). Some complications occurred in both groups, the incidence of observation group was significantly lower than that of control group (P <0.05). Conclusion: The treatment of periodontal disease patients with Cefradine and Qingwei Decoction can significantly reduce the level of serum TNF-α. The clinical efficacy is significant, and the incidence of complications can be reduced, and the safety is better.