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脓毒症性休克是机体对病原体的炎性反应失控,引起循环和微循环功能紊乱,进而导致组织灌注不良,以致引起脑及全身重要器官缺氧。国外文献报道,小儿脓毒性休克病死率为18%～60%,存在先天性或慢性病、多器官功能障碍综合征者病死率>70%。小儿脓毒性休克是儿科重症监护室的重要死亡原因,近年来由于对脓毒症及休克的研究不断深入,认识的不断提高,以及循证医学证据的不断出现,关于脓毒性休克的定义、诊断及治疗都有了一些明显的变化。
Septic shock is the body’s inflammatory response to pathogens out of control, causing circulatory and microcirculation dysfunction, which led to poor tissue perfusion, resulting in brain and vital organs of hypoxia. Foreign literature reports, pediatric septic shock mortality rate of 18% to 60%, there is a congenital or chronic disease, multiple organ dysfunction syndrome mortality was> 70%. Severe septic shock in pediatric intensive care unit is an important cause of death in recent years due to the deepening of the research on sepsis and shock, increasing awareness and evidence-based evidence of the continuous emergence of the definition of septic shock diagnosis And the treatment has made some obvious changes.