口服灭活的产肠毒素性大肠杆菌（ETEC）全菌体加霍乱毒素B亚单位（CTB）菌苗（ETEC/CTB）在成人志愿者的试验是安全的,具有免疫原性。作者在儿童中对ETEC/CTB的安全性和免疫原性进行了评价。选择埃及农村2～5岁和6～12岁健康儿童,以双盲法随机接种菌苗和安慰剂。受种者接种2剂,间隔2周。接种后3天内连续观察不良反应。首剂前1～2天,首剂和第2剂 The orally inactivated enterotoxigenic Escherichia coli (ETEC) whole body plus cholera toxin B subunit (CTB) vaccine (ETEC / CTB) is safe and immunogenic in adult volunteers. The authors evaluated the safety and immunogenicity of ETEC / CTB in children. Selection of healthy children aged 2 to 5 and 6 to 12 years in rural Egypt were randomized to double-blind vaccination and placebo. Subjects were vaccinated 2 doses, two weeks apart. Adverse reactions were observed continuously within 3 days after inoculation. 1 to 2 days before the first dose, the first dose and the second dose