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目的探讨降钙素原(PCT)、C-反应蛋白(CRP)、白细胞(WBC)、中性粒细胞计数(Neu C)、中性粒细胞-淋巴细胞比值(NLR)5种炎性反应指标在幼儿急性上呼吸道感染中的临床价值。方法收集2015年1月-11月首都医科大学昌平教学医院儿科就诊的急性上呼吸道感染幼儿322例,分为细菌组(133例)和病毒组(189例),同时选取60例健康幼儿作为健康对照组,分别测定5种炎性反应指标的含量,比较差异。应用受试者工作特征曲线(ROC)评价5种炎性反应指标对幼儿急性上呼吸道感染的诊断效能。结果 5种炎性反应指标在细菌组含量均高于病毒组和健康对照组,差异有统计学意义(P<0.01)。5种炎性反应指标的ROC曲线下面积分别为93.9%、84.2%、77.7%、81.0%、83.6%。PCT诊断的灵敏度、特异度均高于其他炎症指标。结论 5种炎性反应指标PCT、CRP、WBC、Neu C、NLR均可作为幼儿急性上呼吸道感染的炎症标记物,用于鉴别和辅助诊断细菌性感染。其中PCT诊断效能优于其他炎症指标。
Objective To investigate the expression of 5 inflammatory response indexes, including PCT, CRP, WBC, Neu C, and neutrophil-lymphocyte ratio (NLR) Clinical value of infant acute upper respiratory tract infection. Methods A total of 322 children with acute upper respiratory tract infection admitted to the Pediatrics Department of Changping Teaching Hospital, Capital Medical University from January to November 2015 were enrolled and divided into bacteria group (133 cases) and virus group (189 cases), and 60 healthy children Control group, respectively, the determination of the content of five inflammatory response indicators, compared with the difference. The receiver operating characteristic curve (ROC) was used to evaluate the diagnostic efficacy of five kinds of inflammatory response indexes in children with acute upper respiratory tract infection. Results The contents of five kinds of inflammatory reaction in the bacterial group were higher than those in the virus group and the healthy control group (P <0.01). The areas under the ROC curve of the five inflammatory response indexes were 93.9%, 84.2%, 77.7%, 81.0% and 83.6%, respectively. PCT diagnostic sensitivity, specificity were higher than other indicators of inflammation. Conclusions Five kinds of inflammatory reaction indexes, PCT, CRP, WBC, Neu C and NLR, can be used as inflammatory marker for acute upper respiratory tract infection in children, respectively, to identify and assist in the diagnosis of bacterial infection. Among them, PCT diagnostic efficacy is better than other inflammatory indicators.