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目的 研究转移相关基因VEGF-C在甲状腺癌中的表达及其临床意义。方法 应用免疫组化方法检测45例甲状腺癌组织中的VEGF-C的表达情况。结果 VEGF-C的阳性率在淋巴结转移组(90％)明显高于无淋巴结转移组(80％),P<0.01。在乳头状腺癌中的表达率(91.67％)高于其它病理类型,VEGF-C在良,恶性肿瘤中均有表达。Ⅰ,Ⅱ,Ⅲ期的表达率分别为82.14％,100％,100％,随分期而增加。死亡8例中有6例VEGF-C呈阳性表达。结论 VEGF-C与甲状腺癌的淋巴结转移密切相关,与分期及预后有一定的关系。
Objective To study the expression of metastasis-related gene VEGF-C in thyroid carcinoma and its clinical significance. Methods Immunohistochemistry was used to detect the expression of VEGF-C in 45 cases of thyroid cancer. Results The positive rate of VEGF-C was significantly higher in the lymph node metastasis group (90%) than in the group without lymph node metastasis (80%), P<0.01. The expression rate in the papillary adenocarcinoma (91.67%) was higher than other pathological types, and VEGF-C was expressed in both benign and malignant tumors. The expression rates of stage I, II, and III were 82.14%, 100%, and 100%, respectively, which increased with the stage. Of the 8 deaths, 6 were positive for VEGF-C expression. Conclusion VEGF-C is closely related to the lymph node metastasis of thyroid cancer, and has a certain relationship with stage and prognosis.