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目的了解北京市男男性接触者人类免疫缺陷病毒和肛门人乳头状瘤病毒感染的关系,为我国艾滋病性病防治提供依据。方法通过非政府组织招募男男性接触者进行问卷访谈,采集血液和肛门拭子标本后分别进行HIV-1血清学检测和人乳头瘤病毒DNA基因分型。采用χ2检验、秩和检验、秩相关等方法进行统计分析。结果共调查北京市男男性接触者289人,HIV感染率为10.03%,人乳头瘤病毒感染率为71.63%,生殖器癌/肛门癌病变发生率为0.7%。HIV阳性者高危型HPV感染率高(χ2=9.107,P=0.003),OR=4.178(1.547~11.288),HIV与低危型HPV无统计学关联(χ2=1.714,P=0.190)。HIV阳性者HPV感染基因型的分布与HIV阴性者不同(u=3.266,P=0.001),R=0.192。另外,HIV阳性者高危型HPV感染种类数的分布也与HIV阴性者不同(u=3.740,P=0.000),R=0.220。结论北京市男男性接触者人群HPV感染率、生殖器癌/肛门癌病变发生率较高,HIV与HPV基因型的危险度以及高危型HPV基因种类数相关,提示对HPV疫苗在MSM人群中的应用进行评价研究的必要性。
Objective To understand the relationship between human immunodeficiency virus (HIV) and human papillomavirus infection in men who have sex with men (MSM) in Beijing and to provide evidence for the prevention and control of HIV / AIDS in China. METHODS: A questionnaire interview was conducted among men who had sex with men (MSM) through non-governmental organizations (NGOs). Blood samples and anal swabs were collected for serological detection of HIV-1 and genotyping of human papillomavirus DNA. Using χ2 test, rank sum test, rank correlation and other methods for statistical analysis. Results A total of 289 MSM in Beijing were investigated. The HIV infection rate was 10.03%. The HPV infection rate was 71.63%. The incidence of genital / anal cancer was 0.7%. The HIV positive rate of high-risk HPV infection was high (χ2 = 9.107, P = 0.003), OR = 4.178 (1.547-11.288). There was no significant correlation between HIV and low-risk HPV (χ2 = 1.714, P = 0.190). The distribution of HPV genotypes in HIV-positive individuals was different from those in HIV-negative individuals (u = 3.266, P = 0.001), R = 0.192. In addition, the distribution of high-risk type HPV infection in HIV-positive persons was also different from that of HIV-negative patients (u = 3.740, P = 0.000), R = 0.220. Conclusions The prevalence of HPV infection and genital cancer / anadenocarcinoma among MSM in Beijing is high, and the correlation between HIV and HPV genotype and the number of high-risk HPV genotypes suggest that HPV vaccine is used in MSM population The need for evaluation studies.