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合适的动物模型是研究Graves病 (GD)发病机理和防治措施的基础。目前 ,动物造模的方法包括促甲状腺激素 (TSH)受体多肽或核酸免疫动物、TSH受体转染细胞或TSH受体活化T细胞注入试验动物体内 ,或者采用异体甲状腺组织移植联合外周血单个核细胞、特异性T细胞或自体骨髓细胞输注等。已经建立的准GD动物模型可以产生TSH受体抗体 ,并具有甲状腺炎的某些特征 ,但与人类GD的表现仍有较大差异。抗体滴度的维持和生物学活性的诱导是今后努力的方向。
Appropriate animal models are the basis for studying the pathogenesis and prevention and treatment of Graves disease (GD). Currently, animal modeling methods include administration of thyroid stimulating hormone (TSH) receptor polypeptide or nucleic acid immunization animals, TSH receptor-transfected cells, or TSH receptor-activated T cells into experimental animals, or transplantation of allogeneic thyroid tissue with peripheral blood mononuclear cells Nuclear cells, specific T cells or autologous bone marrow cell infusion. The established quasi-GD animal model can produce TSH receptor antibodies, and some of the features of thyroiditis, but with the performance of human GD are still quite different. The maintenance of antibody titer and the induction of biological activity are the direction of future efforts.