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目的:观察良性前列腺增生(BPH)合并前列腺炎患者国际前列腺症状评分(IPSS)与前列腺按摩液(EPS)和前列腺组织中炎症因子白介素-8(IL-8)、环氧化酶-2(COX-2)水平的相关性。方法:将80例拟行经尿道前列腺电切术(TURP)BPH患者,根据术后病理学诊断分为单纯性增生组(30例)和增生伴炎症组(50例),两组均于术前行IPSS评分、EPS中IL-8、COX-2含量测定,术后前列腺组织中IL-8、COX-2的水平测定,进行统计学分析。结果:增生伴炎症组EPS中IL-8和COX-2水平显著高于单纯性增生组[IL-8:(15.31±1.22)ng/ml vs(5.89±0.91)ng/ml,COX-2:(371.09±14.99)ng/ml vs(156.96±29.47)ng/ml,P均<0.01],前列腺组织中两组IL-8和COX-2水平差异也显著(0.15±0.00 vs 0.05±0.02,0.13±0.01 vs 0.07±0.01,P均<0.01),IPSS两组差异也有显著性[(25.60±5.03)分vs(18.47±4.97)分,P<0.01];单纯增生组中IPSS与EPS和组织中IL-8及COX-2的表达呈中度相关(r=0.712、0.699、0.623、0.731,P均<0.05);增生伴炎症组中IPSS与IL-8、COX-2的表达呈高度相关(r=0.819、0.879、0.798、0.855,P均<0.05)。结论:EPS中IL-8、COX-2水平能间接反映前列腺组织中IL-8、COX-2水平,通过检测患者EPS中IL-8、COX-2水平并结合临床症状可以初步判定BPH患者是否合并前列腺组织学炎症。
OBJECTIVE: To observe the relationship between IPSS and EPS in prostatic hyperplasia (BPH) with prostatitis and the levels of interleukin-8 (IL-8), cyclooxygenase-2 (COX) -2) level of correlation. Methods: Totally 80 BPH patients undergoing TURP were divided into simple hyperplasia group (n = 30) and hyperplastic with inflammation group (n = 50) according to postoperative pathological diagnosis. Both groups were treated with preoperative Line IPSS score, EPS in IL-8, COX-2 content determination, postoperative prostate tissue IL-8, COX-2 levels were measured for statistical analysis. Results: The levels of IL-8 and COX-2 in EPS of hyperplasia with inflammation group were significantly higher than that of simple hyperplasia group [IL-8: (15.31 ± 1.22) ng / ml vs (5.89 ± 0.91) (371.09 ± 14.99) ng / ml vs (156.96 ± 29.47) ng / ml, all P <0.01]. There was also significant difference in the levels of IL-8 and COX-2 between the two groups (0.15 ± 0.00 vs 0.05 ± 0.02, ± 0.01 vs 0.07 ± 0.01, P <0.01). There were also significant differences in IPSS between the two groups [(25.60 ± 5.03) vs (18.47 ± 4.97), P <0.01] The expression of IL-8 and COX-2 were moderately correlated (r = 0.712,0.699,0.623,0.731, P <0.05). The expression of IL-8 and COX-2 in IPSS was highly correlated with r = 0.819,0.879,0.798,0.855, P <0.05). CONCLUSIONS: The levels of IL-8 and COX-2 in EPS may indirectly reflect the levels of IL-8 and COX-2 in prostate tissue. By detecting the levels of IL-8 and COX-2 in EPS of patients and combining with clinical symptoms, Merged with prostate histology inflammation.