论文部分内容阅读
为了解8种典型选矿药剂的毒性,选用小鼠灌胃给药做急性毒性试验。在预试验中确定死亡率为0和100%的剂量后,按改良寇氏法计算其中6种药剂LD_(50),并做出比较。最大耐受量法测定其中2种药剂急性毒性作用。正戊基黄药等6种药剂的小鼠灌胃给药范围为101.7～1611 mg/kg时LD_(50)由大到小的药剂依次为丁胺黑药、十二胺、正戊基黄药、水杨羟肟酸、H_(205)和Z_(200);醚胺GE-601、氧化石蜡皂的最大耐受量分别大于5 000 mg/kg、2 703 mg/kg。根据急性毒性分级标准,醚胺GE-601属于实际无毒的物质,正戊基黄药、丁胺黑药、十二胺、氧化石蜡皂、水杨羟肟酸属于低毒物质,而H_(205)和Z_(200)则属于中等毒物质。
In order to understand the toxicity of 8 kinds of typical dressing pharmaceuticals, mice were selected by gavage for acute toxicity test. After confirming the doses of 0 and 100% mortality in the pretest, six LD_ (50) drugs were calculated according to the modified Kovar method and compared. The maximum tolerability assay was used to determine the acute toxicity of 2 of these agents. N-pentyl xanthate and other six kinds of agents in mice intragastric administration of 101.7 ~ 1611 mg / kg LD_ (50) descending order of drugs as butylamine black, dodecylamine, n-pentyl yellow The maximum tolerated dose of drug, salicyclic hydroxamic acid, H_ (205) and Z_ (200), etheramine GE-601 and oxidized paraffin soap were more than 5 000 mg / kg and 2 703 mg / kg, respectively. According to the classification criteria of acute toxicity, ether amine GE-601 belongs to the actual non-toxic substances. The n-pentyl xanthate, butylamine black drug, dodecylamine, oxidized paraffin soap and salicyclic hydroxamic acid belong to low toxic substances, And Z_ (200) are moderately toxic substances.