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微核检测表明,20例十二指肠溃疡患者服用西咪替丁后,检出微核率较服药前明显增高。据文献报道,西咪替丁可引起人类染色体损伤。本研究表明,西咪替丁可能有致诱变的潜在危险。
The micronucleus test showed that 20 patients with duodenal ulcer after taking cimetidine, micronucleus rate was significantly higher than before treatment. According to the literature, cimetidine can cause human chromosome damage. This study shows that cimetidine may have the potential for mutagenicity.