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目的 :研究转化生长因子 α(TGFα)及其受体表皮生长因子受体 (EGFR)在鼻息肉组织中的表达情况及与增殖细胞核抗原 (PCNA)表达的关系。方法 :应用免疫组织化学技术检测 2 0例鼻息肉组织中 TGFα、EGFR和 PCNA的表达及分布情况。结果 :鼻息肉组织中上皮细胞、腺上皮细胞及炎性细胞 TGFα、EGFR和 PCNA高表达 ,且上皮细胞、腺上皮细胞 TGFα、EGFR的表达与 PCNA的表达呈显著正相关。结论 :TGFα可能通过促进上皮细胞、腺上皮细胞的增殖而促进鼻息肉的形成和发展。
Objective: To investigate the expression of transforming growth factor α (TGFα) and its receptor epidermal growth factor receptor (EGFR) in nasal polyps and its relationship with the expression of proliferating cell nuclear antigen (PCNA). Methods: Immunohistochemistry was used to detect the expression and distribution of TGFα, EGFR and PCNA in 20 cases of nasal polyps. Results: The expressions of TGFα, EGFR and PCNA in epithelial cells, glandular epithelial cells and inflammatory cells in nasal polyps were highly expressed. The expressions of TGFα and EGFR in epithelial cells and glandular epithelial cells were positively correlated with the expression of PCNA. Conclusion: TGFα may promote the formation and development of nasal polyps by promoting the proliferation of epithelial cells and glandular epithelial cells.