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目的分析朱砂莲中毒导致急性肾功能衰竭临床表现、肾脏病理学及相关文献复习。方法 2007年3月-9月收治朱砂莲中毒急性肾功能衰竭2例,分析临床表现及肾脏病理损害。结果朱砂莲急性中毒易致急性肾功能衰竭,危及生命;其主要损害肾小管间质,表现为急性肾小管重度损伤,无炎性细胞浸润,而肾小球几乎无病变。结论朱砂莲为我国常使用中药,主要成分为马兜铃酸,易致马兜铃酸肾病,须提高对该病认识,规范使用中草药,避免药物性所致肾损害。
Objective To analyze the clinical manifestations of acute renal failure caused by Asarum muridatus, renal pathology and related literature review. Methods From March 2007 to September 2007, two cases of acute renal failure with Asplenium indicum poisoning were treated, and their clinical manifestations and renal pathological changes were analyzed. Results The acute toxicity of Zhusha Lin acute toxicity caused acute renal failure, life-threatening; its main damage to the tubulointerstitium, showed severe acute tubular injury, no inflammatory cell infiltration, and almost no glomerular lesions. Conclusion Zhu sand lotus is often used Chinese medicine, the main ingredient is aristolochic acid, easy to cause aristolochic acid nephropathy, to improve understanding of the disease, regulate the use of Chinese herbal medicine, to avoid drug-induced renal damage.