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目的了解伴下尿路症状(LUTS)的良性前列腺增生(BPH)患者的生活质量。方法88例具有典型LUTS的BPH患者,平均年龄68岁。患者治疗前均行国际前列腺症状评分(IPSS)、勃起功能国际问卷(IIEF-5)、简明性功能问卷(BSFI)、焦虑自评量表、老年抑郁量表和BPH影响指数问卷(BII)调查,同时检测尿流率、前列腺体积和血清睾酮。应用多元逐步回归分析方法和一元相关回归分析方法评价各检测变量间的相关性。结果统计学分析显示：年龄与BSFI中勃起功能和IIEF-5有显著相关性(r=-0.552和r=-0.567,P=0.000),IPSS评分与年龄有显著相关性(r= 0.213,P=0.047),BII与年龄无明显相关性。IPSS评分与BSFI中勃起功能和满意度有显著相关性(r=-0.332,P=0.002；r=0.302,P=0.005),IPSS与BII间有显著相关性(r=0.420,P=0.000)。BII与抑郁评分间有显著相关性(r=0.426,P=0.002)。最大尿流率、前列腺体积和睾酮与BII评分间无明显相关性。结论LUTS对BPH患者的日常生活、性功能和心理有明显影响,BPH治疗前需重视老年患者的心理和生活质量。
Objective To understand the quality of life of patients with benign prostatic hyperplasia (BPH) with lower urinary tract symptoms (LUTS). Methods 88 patients with typical LUTS BPH patients, mean age 68 years. Before treatment, patients were assessed with International Prostate Symptom Score (IPSS), IIEF-5, BSFI, Self-rating Anxiety Scale, Geriatric Depression Scale and BPH Impact Index Questionnaire (BII) Urine flow rate, prostate volume and serum testosterone were measured simultaneously. Multiple stepwise regression analysis and univariate correlation regression analysis were used to evaluate the correlation between the variables. Results Statistical analysis showed that there was a significant correlation between age and erectile function and IIEF-5 in BSFI (r = -0.552 and r = -0.567, P = 0.000). There was a significant correlation between IPSS and age (r = 0.213, P = 0.047), BII and age no significant correlation. There was a significant correlation between IPSS and erectile function and satisfaction in BSFI (r = -0.332, P = 0.002; r = 0.302, P = 0.005) . There was a significant correlation between BII and depression scores (r = 0.426, P = 0.002). There was no significant correlation between maximum flow rate, prostate volume, and testosterone and BII scores. Conclusions LUTS has a significant effect on daily life, sexual function and psychology in patients with BPH. Psychological and quality of life should be emphasized in elderly patients before BPH treatment.