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目的:研究169例急性冠脉综合征(ACS)患者和94例健康人血清血管紧张素转换酶(ACE)活性水平,及与ACE基因插入(Ⅰ)和(或)缺失(D)多态性的关系。方法:采用多聚酶链反应(PCR)法。结果:急性冠脉综合征患者的血清ACE活性明显高于健康人,这种差异主要表现在DD型和ID型个体中。结论:在中国汉族人群中ACE基因Ⅰ和(或)D多态性变异与血清ACE活性水平有关,它是急性冠脉综合征的一个独立的危险因素。
AIM: To investigate the serum levels of angiotensin-converting enzyme (ACE) in 169 patients with acute coronary syndrome (ACS) and 94 healthy controls, and to investigate the relationship between ACE gene insertion (Ⅰ) and / or deletion Relationship. Methods: Polymerase chain reaction (PCR) was used. Results: Serum ACE activity in patients with acute coronary syndrome was significantly higher than that in healthy individuals. This difference was mainly found in DD and ID individuals. CONCLUSION: The polymorphisms of ACE gene Ⅰ and / or D in Chinese Han population are related to serum ACE activity level, which is an independent risk factor for acute coronary syndrome.