论文部分内容阅读
自然杀伤(NK)细胞是最重要的抗肿瘤免疫细胞。提高NK细胞抗瘤活性的最新研究包括:同种异体NK细胞过继性免疫治疗;通过基因工程的方法使肿瘤细胞表达肿瘤抗原特异性嵌合受体;选择具有高亲和力Fc受体NK细胞,联合单克隆抗体通过ADCC效应杀伤肿瘤细胞;提高靶细胞对NK细胞介导的凋亡的敏感性;解除抑制因素对NK细胞的影响;促进NK细胞浸润肿瘤组织及淋巴结;NK细胞不同亚群间的功能差异研究。
Natural killer (NK) cells are the most important anti-tumor immune cells. New research to improve the anti-tumor activity of NK cells include: adoptive immunotherapy of allogenic NK cells; tumor-specific expression of tumor antigen-specific chimeric receptors by genetic engineering; selection of NK cells with high affinity Fc receptors, Monoclonal antibodies kill tumor cells by ADCC effect; increase the sensitivity of target cells to NK cell-mediated apoptosis; release of inhibitory factors on NK cells; promote the infiltration of NK cells into tumor tissues and lymph nodes; and between different subsets of NK cells Functional differences research.