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目的:研究新生儿及成人指皮组织CD11c阳性细胞的数量、形态和分布情况。方法:取7例尸检新生儿及5例成人无名指指皮组织样本,CD11c标记,行免疫组织化学染色,光镜观察阳性细胞的表达、分布情况并进行统计学分析。结果:人指皮组织中,CD11c阳性细胞和阳性突起呈棕褐色,胞体大小不等、形态多样;胞核呈圆形或椭圆形,突起长短粗细不等,可相互连接。阳性细胞呈散在或灶带状分布,灶带状分布常见于表皮乳头周围、血管神经分叉周围,血管外膜、环层小体被囊结缔组织内可见散在的CD11c阳性细胞。新生儿组CD11c阳性细胞的表达率为(31.0±9.4)%,高于成人组(6.0±2.7)%(P<0.01)。结论:CD11c分子可能也是人指皮组织细胞分化过程中的阶段性标志物,其表达量的降低与年龄的增长有关。
Objective: To study the number, shape and distribution of CD11c positive cells in neonatal and adult finger dermis. Methods: Seven cases of autopsy neonates and five adult fingerless finger samples were stained with CD11c. Immunohistochemistry and immunohistochemistry were used to observe the expression and distribution of positive cells. Statistical analysis was performed. Results: Human finger dermis, CD11c positive cells and positive protrusions were tan, cell body size range, diverse morphology; nucleus was round or oval, the length of the protrusions ranging in thickness, can be connected to each other. Positive cells were scattered or zonal distribution, zona fasciata distribution around the epidural papilla, around the vascular nerve bifurcation, adventitia, and corpuscles were seen in the cystic connective tissue scattered CD11c positive cells. The positive rate of CD11c positive cells in newborn group was (31.0 ± 9.4)%, higher than that in adult group (6.0 ± 2.7)% (P <0.01). Conclusion: The CD11c molecule may also be a stage marker in the differentiation of human finger dermal cells. The decreased expression of CD11c may be related to the increase of age.