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目的 探讨细胞间粘附分子 1(CD5 4)在直肠癌组织和邻近肠粘膜组织的表达及临床意义。方法 应用荧光标记的CD5 4单克隆抗体分子探针 ,通过流式细胞仪检测 ,对 3 6例直肠癌癌组织、癌下缘 2cm处肠粘膜组织及患者正常结肠粘膜组织的CD5 4表达进行了对比研究。结果 直肠癌组织CD5 4表达阳性率为 9.79%± 5 .12 % ,与癌下缘 2cm处肠粘膜之差异无显著性意义 (P >0 .0 5 ) ,但显著高于正常结肠粘膜和对照组 (P <0 .0 5 )。结论 CD5 4在直肠癌组织中的高表达 ,可作为直肠癌临床研究的指标 ;癌下缘 2cm处肠粘膜CD5 4表达与直肠癌组织相似 ,有恶性转化的趋势。
Objective To investigate the expression and clinical significance of intercellular adhesion molecule 1 (CD5 4) in rectal cancer tissues and adjacent intestinal mucosa. Methods The expression of CD5 4 in 36 rectal cancer tissues, 2 cm in the lower margin of the intestinal mucosa, and normal colonic mucosa tissues were detected by flow cytometry using fluorescently labeled CD4 4 monoclonal antibody molecular probes. Comparative Study. Results The positive rate of CD4 4 expression in rectal cancer tissue was 9.79%±5.12%. There was no significant difference between the rectal cancer and the intestinal mucosa at the lower edge of the tumor (P > 0.05), but it was significantly higher than that of normal colon mucosa and control. Group (P <0. 0 5). Conclusion The high expression of CD5 4 in rectal cancer can be used as an indicator of rectal cancer clinical research. The expression of CD5 4 in the intestinal mucosa at the lower edge of the cancer is similar to that of rectal cancer and has a tendency of malignant transformation.