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目的探讨影响自然周期夫精宫腔内人工授精(intrauterine insemination,IUI)成功率的因素。方法回顾性分析2008年6月-2010年6月期间236例自然周期排卵后进行单次宫腔内人工授精的284个周期的临床资料。结果每周期临床妊娠率为11.3%。不同病因及不同年龄间的临床妊娠率无显著性差异(P>0.05)。IUI日的卵泡大小、子宫内膜厚度及形态、是否用hCG、禁欲天数在妊娠组、非妊娠组间无显著性差异。不孕不育超过5年者成功率显著降低(P=0.03)。妊娠组IUI日处理后的前向运动精子总数明显高于非妊娠组,有统计学差异(P=0.03)。结论自然周期人工授精是简单实用的助孕方法,具有临床可行性。
Objective To explore the factors influencing the success rate of intrauterine insemination (IUI) Methods The clinical data of 236 cycles of single intrauterine insemination after 236 cycles of ovulation from June 2008 to June 2010 were retrospectively analyzed. Results The clinical pregnancy rate per week was 11.3%. There was no significant difference in clinical pregnancy rates between different causes and different ages (P> 0.05). IUI day follicular size, endometrial thickness and morphology, whether to use hCG, abstinence days in the pregnancy group, non-pregnancy group no significant difference. The success rate of infertility for more than 5 years was significantly lower (P = 0.03). The total number of forward motile sperm after IUI treatment in pregnancy group was significantly higher than that in non-pregnant group (P = 0.03). Conclusion Natural cycle artificial insemination is a simple and practical method of pregnancy, with clinical feasibility.