抗生素及磺胺类抗微生物作用的发现,使疾病开始有了特异性的治疗。新抗生素的研制给疾病的治疗带来了实惠,但也带来了许多毒副作用。抗生素的滥用是目前国内存在较严重的问题之一,笔者曾撰文谈及临床上滥用、无限制地增加剂量、无目的的联合用药都会引起肾脏损害。随着抗生素在临床上的广泛应用,新抗生素的不断问世,非处方乱售抗生素现象的普遍存在,抗生素类药物引起的药物性急性间质性肾炎发生率 Antibiotics and sulfa antimicrobial effects of the discovery, the disease began with a specific treatment. The development of new antibiotics has brought benefits to the treatment of diseases, but also brought many side effects. Abuse of antibiotics is currently one of the more serious problems in the country, the author has written about the clinical abuse, unlimited increase in dosage, combined with no purpose will cause kidney damage. With the widespread use of antibiotics in clinical practice, the advent of new antibiotics, the prevalence of over-the-counter antibiotics, the incidence of drug-induced acute interstitial nephritis caused by antibiotics