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本实验对吗啡依赖大鼠侧脑室注射５—ＨＴ受体激动剂，可增强其戒断反应强度，并呈量效关系。而注射５—ＨＴ受体阻断剂肉桂硫胺时，则减轻其戒断反应程度，也呈量效关系。同时还发现用５—ＨＴ化学切断剂５，６－双羟色胺破坏大鼠中缝５—ＨＴ神经元后，吗啡戒断反应显著减弱。因此５－ＨＴ受体阻断剂和５—ＨＴ化学切断剂可对开发临床脱毒治疗药物提供有意义的参考。
In this experiment, morphine-dependent rats injected into the lateral ventricle of 5-HT receptor agonist, can enhance the withdrawal response intensity, and the dose-response relationship. Injection of 5-HT receptor blocker cinnamamine, then relieve their withdrawal response, but also a dose-response relationship. At the same time, it was also found that the morphine withdrawal response was significantly weakened after the rat 5-HT neurons were damaged by 5-HT chemical scavenger 5,6-serotonin. Therefore, 5-HT receptor blockers and 5-HT chemical sealers can provide a meaningful reference for the development of clinical detoxification drugs.