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对聚合物植入生物体的生物降解性一直为人们所重视。有关文献报道聚乙烯(PE)绝绿体起搏器电极正是因为植入病人体内极不稳定,使得此项研究未成功。已证实PE在生物体的生理环境中的化学变化可能为酶的一种特性,但是至今未完全肯定有哪些酶及其作用机制对PE降解的影响。本文对鼠肝脏微粒体碎片的细胞色素P—450的刺激和抑制以影响PE的氧化
Biodegradability of polymer implanted organisms has always been valued. It is reported in the literature that polyethylene (PE) pacemaker electrode is precisely because of implantation in patients with extremely unstable, making the study unsuccessful. It has been confirmed that the chemical changes of PE in the physiological environment of the organism may be a characteristic of the enzyme, but so far it has not been completely affirmed which enzymes and their mechanism of action affect the degradation of PE. In this article, stimulation and inhibition of cytochrome P-450 in rat liver microsomal fragments to affect PE oxidation