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光学多普勒成像(Optical Doppler tomography,ODT)是一种结合了光学相干层析成像技术(Opticalcoherence tomography,OCT)和多普勒流速仪的非侵入、非接触的成像技术,能够实现对高散介质组织内部的血管分布和血液流速的探测。阐述了基于数字希尔伯特变换的相位分离多普勒光学相干层析成像技术的工作原理,并且通过对玻璃毛细管和生物芯片微通道管中聚苯乙烯溶液流速的实验测量,准确测量管内微粒缓慢移动时的多普勒频移量,获得了玻璃管内和生物芯片微通道管中流速分布曲线,证实了所提方法的可行性。获取的多普勒图像具有较高的空间分辨力和速度分辨力,在未来的临床应用中有潜在的应用价值。
Optical Doppler tomography (ODT) is a noninvasive, non-invasive imaging technique that combines optical coherence tomography (OCT) and Doppler velocimetry to enable high-dispersion Vascular tissue within the distribution and blood flow velocity detection. The principle of phase separation Doppler optical coherence tomography based on digital Hilbert transform is described, and the experimental measurement of the flow rate of polystyrene solution in glass capillary and biochip microchannel tube is used to accurately measure the intra- The Doppler frequency shift when moving slowly and obtaining the flow velocity distribution curve in the microchannel tube of biochip and glass tube confirmed the feasibility of the proposed method. The obtained Doppler images have high spatial resolution and speed resolution, and have potential application value in future clinical application.