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目的分析慢性乙型肝炎合并焦虑症患者生存质量及免疫指标的变化情况,为患者的诊断与治疗提供依据。方法选取2014年1月-2015年11月于医院进行治疗的慢性乙型肝炎合并焦虑症患者48例为观察组,慢性乙型肝炎患者48例为对照组,将对照组和观察组生存质量及红细胞免疫、细胞免疫指标进行比较,同时比较观察组轻度、中度及重度焦虑症患者的生存质量及红细胞免疫、细胞免疫指标。结果观察组生存质量方面包括生理方面、心理方面、社会关系及环境领域的评分分别为(52.21±5.40)分、(54.22±5.61)分、(50.17±4.82)分及(58.81±5.80)分,其低于对照组(61.32±5.79)分、(65.42±6.13)分、(60.28±5.46)分及(70.64±6.57)分,观察组红细胞免疫及细胞免疫指标也均差于对照组,且观察组轻度、中度及重度焦虑症患者的生存质量及红细胞免疫、细胞免疫指标也存在明显差异,差异有统计学意义(P<0.05)。结论慢性乙型肝炎合并焦虑症患者生存质量及免疫指标相对较差,且焦虑程度对其评估结果也有较大影响,因此应重视慢性乙型肝炎患者焦虑症的治疗。
Objective To analyze the changes of quality of life and immune parameters in patients with chronic hepatitis B and anxiety and provide the basis for the diagnosis and treatment of patients. Methods Forty-eight patients with chronic hepatitis B and anxiety who were treated in hospital from January 2014 to November 2015 were selected as observation group and 48 patients with chronic hepatitis B as control group.The quality of life and Erythrocyte immunity and cellular immune indexes were compared. The quality of life, erythrocyte immunity and cellular immune indexes in patients with mild, moderate and severe anxiety in the observation group were also compared. Results The quality of life of the observation group was 52.21 ± 5.40, 54.22 ± 5.61, 50.17 ± 4.82 and 58.81 ± 5.80 in the aspects of physiology, psychology, social relations and environment, respectively. (61.32 ± 5.79) points, (65.42 ± 6.13) points, (60.28 ± 5.46) points and (70.64 ± 6.57) points respectively. The indexes of erythrocyte immunity and cellular immunity of the observation group were also worse than those of the control group The quality of life, erythrocyte immunity and cellular immunity index of patients with mild, moderate and severe anxiety were also significantly different (P <0.05). Conclusion The quality of life and immune index of patients with chronic hepatitis B and anxiety disorders are relatively poor, and the degree of anxiety has a greater impact on the assessment results. Therefore, the treatment of anxiety in patients with chronic hepatitis B should be emphasized.