患儿,女,5岁6个月,以“运动、语言能力进行性退步3年”就诊。患儿2岁6个月生长发育基本同正常同龄儿,2岁6个月后无明显原因手部“捏”、“撕”等精细动作逐渐消失,出现无目的的“扭手”、“搓手”表现,主动语言逐渐减少至消失,常有过度换气发作,面部常表露一种“社交性微笑”, Children, female, 5 years old 6 months, with “exercise, language ability to progressively retreat 3 years” treatment. The growth and development of children aged 2 months and 6 months were basically the same as those of normal children, and there was no obvious reason after 2 years and 6 months. The delicate movements such as hand pinching and tearing disappeared gradually, Hand “performance, the active language gradually reduced to disappear, often hyperventilation episodes, the face often reveals a” social smile "