B淋巴细胞刺激因子是B细胞生长、发育和分化中重要的免疫调控因子,其过度表达可能参与系统性红斑狼疮(systemiclupuserythematosus,SLE)发病机制中自身反应性B细胞的产生和自身免疫耐受的失衡。鉴于BlyS具有明显的B细胞趋向性,针对BLyS靶目标研制特异性抗体、相应受体或人可溶性BLyS结合小肽等,通过特异性封闭BLyS的免疫调控信号,拮抗其诱导的T、B淋巴细胞的高度活化和病理性自身抗体的产生,有望开辟一条治疗SLE等自身免疫病的新途径。 B lymphocyte stimulating factor is an important immunoregulatory factor in the growth, development and differentiation of B cells. Its overexpression may be involved in the production of auto-reactive B cells and autoimmune tolerance in the pathogenesis of systemic lupus erythematosus (SLE) Imbalance In view of BlyS has obvious B cell tropism, targeting BLyS target specific antibodies, corresponding receptors or human soluble BLyS binding small peptides, etc., by specifically blocking BLyS immune regulatory signal, antagonized its induced T, B lymphocytes The highly activated and pathogenic autoantibodies, is expected to open up a new way to treat autoimmune diseases such as SLE.