《Lancet》1984;1(8380):772。探讨类风湿性关节炎的病毒病因学主要是依靠信念和应用免疫病理学的类推法,而不是获得明确的证据而支持的。类风湿性滑膜的免疫增生现象与局部抗原的刺激作用相同。至今除免疫球蛋白本身外,仍未发现特异性抗原。因此,由于这些假设中的抗原有难以捉摸的特点,因而促使人们提出了一个看法,即病毒可能是这些抗原的来源,但仍然不能检查出。现已有许多实验性和天然病毒感染的实例,在这些感染中,病毒除刺激产生多种免疫反应外, Lancet 1984; 1 (8380): 772. The viral etiology of rheumatoid arthritis is mainly based on beliefs and the use of immunopathology rather than explicit evidence. Rheumatoid synovial immune proliferation and local antigen stimulation. So far in addition to the immunoglobulin itself, still no specific antigen found. Because of the elusive nature of the antigens in these assumptions, therefore, there is a belief that the virus may be the source of these antigens but still not detectable. There are many examples of experimental and natural viral infections in which the virus, in addition to stimulating a variety of immune responses,