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目的:观察肝动脉栓塞(TACE)联合射频消融(RFA)治疗中晚期肝癌的效果。方法:选择原发性肝癌100例,随机分为观察组55例,对照组45例。观察组采用TACE联合RFA治疗,对照组仅采用TACE治疗,观察比较两组肿瘤血供消失及肿瘤坏死情况,1年、3年和5年生存率及不良反应发生情况等。结果:观察组肿瘤血供消失率、肿瘤坏死>90%和肿瘤完全坏死率均显著高于对照组(P<0.05);1年、3年和5年生存率显著或非常显著长于对照组(P<0.05,P<0.01);不良反应发生率显著低于对照组(P<0.05)。结论:TACE联合RFA治疗中晚期肝癌效果优于单用TACE治疗。
Objective: To observe the effect of hepatic artery embolization (TACE) combined with radiofrequency ablation (RFA) in the treatment of advanced hepatocellular carcinoma. Methods: 100 cases of primary liver cancer were randomly divided into observation group (55 cases) and control group (45 cases). The observation group was treated with TACE combined with RFA, while the control group was treated with TACE alone. The tumor blood supply and tumor necrosis, the 1-year, 3-year and 5-year survival rates and adverse reactions were compared between the two groups. Results: The rates of tumor blood supply, tumor necrosis> 90% and tumor complete necrosis in the observation group were significantly higher than those in the control group (P <0.05). The 1-year, 3-year and 5-year survival rates were significantly or very significantly longer than those in the control group P <0.05, P <0.01). The incidence of adverse reactions was significantly lower than that of the control group (P <0.05). Conclusion: TACE combined with RFA is superior to TACE in the treatment of advanced hepatocellular carcinoma.