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目的探讨血管内皮细胞生长因子(VEGFmRNA)和碱性成纤维细胞生长因子(bFGFmRNA)在原发性胃癌中的表达及意义。方法应用原位杂交技术检测56例胃癌患者VEGFmRNA和bFGFmRNA的表达情况。结果胃癌患者VEGFmRNA和bFGFmRNA表达水平明显高于正常人,与胃癌血管侵犯、淋巴结受累、肝脏转移及临床病理分期密切相关,与肿瘤大小、部位、年龄、性别、生长方式及组织学类型等因素无关。结论VEGFmRNA和bFGFmRNA表达水平与胃癌的浸润、转移密切相关,可作为原发性胃癌的预后指标,可望为抑制原发性胃癌血管生成治疗提供实验依据。
Objective To investigate the expression and significance of vascular endothelial growth factor (VEGFmRNA) and basic fibroblast growth factor (bFGFmRNA) in primary gastric cancer. Methods The expressions of VEGF mRNA and bFGF mRNA in 56 patients with gastric cancer were detected by in situ hybridization. Results The expression of VEGF mRNA and bFGF mRNA in gastric cancer patients was significantly higher than that in normal people, which was not related to the factors such as vascular invasion, lymph node involvement, liver metastasis and clinical stage in gastric cancer, but not with tumor size, location, age, sex, growth pattern and histological type . Conclusions The expression of VEGF mRNA and bFGF mRNA is closely related to the infiltration and metastasis of gastric cancer, which can be used as a prognostic indicator of primary gastric cancer. It is expected to provide experimental evidence for the suppression of angiogenesis in primary gastric cancer.