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In search of novel anticancer agents,a series of N-methyl colchiceinamide derivatives(7a-7i) containing 1,3,4-thiadiazole moieties were synthesized,and their structures were confirmed by spectral analysis. Cytotoxicity of these compounds was evaluated by MTT assay in vitro against four human tumor cell lines,i.e.A2780,A549,BEL7402,and MCF-7.The results indicated that most of the derivatives showed significant anticancer activities,particularly,compounds 7h and 7i showed more potent cytotoxic activities of all screened cancer cells than colchicine.
In a search of novel anticancer agents, a series of N-methyl colchiceinamide derivatives (7a-7i) containing 1,3,4-thiadiazole moieties were synthesized, and their structures were confirmed by spectral analysis. Cytotoxicity of these compounds was evaluated by MTT assay in vitro against four human tumor cell lines, ieA2780, A549, BEL7402, and MCF-7.The results indicated that most of the derivatives showed marked anticancer activities, particularly, compounds 7h and 7i showed more potent cytotoxic activities of all screened cancer cells than colchicine.