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目的探讨血清生长停滞特异性基因产物6(GAS6)水平与T2DM、肥胖的相关性及临床意义。方法新诊断T2DM患者(T2DM组)46例和NGT者(NGT组)42名按BMI 18.5kg/m2 25kg / . Fasting serum GAS6 levels were measured by ELISA. Results Serum concentration of GAS6 in T2DM group was lower than that in NGT group [(10.63 ± 1.95) vs (14.27 ± 3.82) ng / ml] (P <0.01). Partial correlation analysis showed that serum GAS6 was negatively correlated with BMI, WC, FPG, HbA1c, C-RP, TNF-α and IL-6 (r = -0.235, -0.266, -0.362, -0.427, -0.268, 0.442, -0.380, P <0.05 or P <0.01), and was positively correlated with HDL-C (r = 0.235, P <0.05). Multivariate stepwise regression analysis showed that BMI, HbA1c and TNF-α (β, -0.190, -0.483, -0.580, respectively) were independent influencing factors of serum GAS6 level. Conclusions Serum GAS6 levels in T2DM patients are lower than those in NGT patients. BMI, HbA1c, TNF-α and GAS6 are independently and inversely correlated.