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目的观察阿奇霉素较长疗程治疗小儿支原体肺炎(MP)的疗效。方法选取医院收治的102例MP患儿进行较长疗程的阿奇霉素治疗,疗程为7d,检测并比较患儿治疗前后C反应蛋白(CRP)和人免疫球蛋白(Ig G、Ig A和Ig M)的水平,并评价疗效。结果经过1个疗程的阿奇霉素治疗,显效74例(72.55%),有效24例(23.53%),无效4例(3.92%),总有效率为96.08%。102例小儿肺炎支原体肺炎患儿治疗后CRP降低,免疫球蛋白水平均升高,差异均有统计学意义(P<0.05)。共计出现不良反应11例(10.78%),其中胃肠道反应5例、局部疼痛感3例,皮疹3例,不良反应较为轻微,经对症处理后消失。结论 CRP和人免疫球蛋白可作为肺炎支原体早期诊断和监测治疗的有效指标,阿奇霉素较长疗程治疗MP疗效确切,不良反应少,值得临床应用。
Objective To observe the long course of azithromycin treatment of children with mycoplasma pneumonia (MP) curative effect. Methods A total of 102 children with MP who were admitted to hospital for a longer course of azithromycin treatment were treated for 7 days. The levels of C-reactive protein (CRP) and human immunoglobulin (Ig G, Ig A and Ig M) Level, and evaluate the efficacy. Results After a course of azithromycin treatment, 74 cases (72.55%) were effective, 24 cases (23.53%) were effective, 4 cases (3.92%) were ineffective, and the total effective rate was 96.08%. After treatment of 102 cases of children with Mycoplasma pneumoniae pneumonia, the CRP was decreased and the immunoglobulin levels were increased, the differences were statistically significant (P <0.05). There were 11 adverse reactions (10.78%) in total, including 5 cases of gastrointestinal reaction, 3 cases of local pain and 3 cases of skin rash. The adverse reactions were mild and disappeared after symptomatic treatment. Conclusion CRP and human immunoglobulin can be used as an effective indicator for the early diagnosis and monitoring of Mycoplasma pneumoniae. The longer duration of treatment with azithromycin is more effective and the fewer adverse reactions are worthy of clinical application.