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目的探讨TLR4蛋白在胃癌及癌前病变组织中表达及与幽门螺杆菌感染的关系。方法免疫组化SP法检测慢性胃炎(CSG)41例、肠上皮化生(IM)36例、不典型增生(Dys)35例和胃癌(GC)44例标本中TLR4蛋白的表达,Giemsa染色法检测幽门螺杆菌。结果 TLR4在CSG、IM、Dys、GC胃黏膜中均有表达。在幽门螺杆菌阳性组中,TLR4蛋白表达明显高于幽门螺杆菌阴性组[CSG,(66.7%vs.33.3%);IM,(63.0%vs.37.0%);Dys,(57.7%vs.42.3%);GC,(61.8%vs.38.2%)](P<0.05)。结论 TLR4蛋白与幽门螺杆菌感染相互作用导致胃黏膜病变。
Objective To investigate the expression of TLR4 protein in gastric carcinoma and precancerous lesions and its relationship with Helicobacter pylori infection. Methods Immunohistochemical SP method was used to detect the expression of TLR4 protein in 41 cases of chronic gastritis (CSG), 36 cases of intestinal metaplasia (IM), 35 cases of dysplasia (Dys) and 44 cases of gastric carcinoma (GC). Giemsa staining Helicobacter pylori detection. Results TLR4 was expressed in gastric mucosa of CSG, IM, Dys and GC. In Helicobacter pylori positive group, TLR4 protein expression was significantly higher than that in Helicobacter pylori negative group [CSG, (66.7% vs.33.3%); IM, (63.0% vs.37.0%); Dys, (57.7% vs.42.3 %); GC, (61.8% vs.38.2%)] (P <0.05). Conclusion Interaction between TLR4 protein and Helicobacter pylori infection leads to gastric mucosal lesions.