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目的:探讨盐碘含量调整后济南市孕早期孕妇甲状腺激素医学参考值范围，为临床孕早期孕妇甲状腺疾病的诊治提供依据。方法:采用前瞻性研究方法，选择2018年1-12月在山东省妇幼保健院产检并进行甲状腺功能检测的孕早期（0~13周）孕妇560例作为调查对象；同时，选择同一时间段在山东省妇幼保健院健康查体中心体检的健康非妊娠妇女100例作为对照人群。采集孕早期孕妇尿样，采用砷铈催化分光光度法检测尿碘含量。采集孕早期孕妇和对照人群静脉血，采用电化学发光法检测血清游离三碘甲状腺原氨酸（FTn 3）、游离甲状腺素（FTn 4）、促甲状腺激素（TSH）水平，建立FTn 3、FTn 4和TSH的医学参考值范围。n 结果:孕早期孕妇尿碘中位数为162.21 μg/L，处于碘适宜水平。盐碘含量调整后孕早期孕妇FTn 3、FTn 4、TSH医学参考值范围分别为3.86~6.15 pmol/L、12.56~22.16 pmol/L、0.01~3.48 mU/L；对照人群FTn 3、FTn 4、TSH医学参考值范围分别为3.55~6.05 pmol/L、9.93~20.58 pmol/L、0.54~5.92 mU/L。n 结论:盐碘含量调整后济南市孕早期孕妇碘营养处于适宜水平。孕早期孕妇FTn 3、FTn 4、TSH医学参考值范围不同于健康非妊娠妇女，因此建立孕早期孕妇甲状腺激素医学参考值范围具有临床意义。n “,”Objective:To explore the range of medical reference value of thyroid hormone of pregnant women in early pregnancy in Jinan after adjustment of salt iodine content, so as to provide basis for clinical diagnosis and treatment of thyroid diseases of pregnant women in early pregnancy.Methods:A prospective study was conducted in 560 pregnant women in early pregnancy (0-13 weeks) who had underwent prenatal examination and thyroid function testing in Shandong Provincial Maternal and Child Health Care Hospital from January to December 2018. At the same time, 100 healthy non-pregnant women who were examined in the Health Examination Center of Shandong Provincial Maternal and Child Health Care Hospital were selected as the control population. Urine samples of pregnant women in early pregnancy were collected, and urinary iodine content was detected by arsenic cerium catalytic spectrophotometry. Venous blood samples were collected from pregnant women in early pregnancy and control population, the serum levels of free triiodothyronine (FTn 3), free thyroxine (FTn 4) and thyroid stimulating hormone (TSH) were detected by electrochemiluminescence (ECL), and the medical reference values of FTn 3, FTn 4 and TSH were established.n Results:The median urinary iodine of pregnant women in early pregnancy was 162.21 μg/L, which was in the appropriate level of iodine. After the adjustment of salt iodine content, the medical reference values of FT n 3, FTn 4 and TSH in pregnant women in early pregnancy were 3.86-6.15 pmol/L, 12.56-22.16 pmol/L and 0.01-3.48 mU/ L, respectively; and the medical reference values of FTn 3, FTn 4 and TSH in control population were 3.55-6.05 pmol/L, 9.93-20.58 pmol/L and 0.54-5.92 mU/L, respectively.n Conclusions:The iodine nutrition of pregnant women in early pregnancy in Jinan is appropriate after the adjustment of salt iodine content. The medical reference values of FTn 3, FTn 4 and TSH in pregnant women in early pregnancy are different from those in the healthy non-pregnant women. Therefore, it is of clinical significance to establish a medical reference value range of thyroid hormone for pregnant women in early pregnancy.n