论文部分内容阅读
目的:探讨甲状腺功能低下和甲状腺功能亢进时甲状腺激素对大鼠血清瘦素水平影响。方法:应用他巴唑和优甲乐人工造成大鼠甲状腺功能低下和甲状腺功能亢进状态,分别检测用药10天、停药10天和正常对照大鼠血清瘦素、T_3、T_4、TSH浓度、体重。结果:甲低、甲亢和正常对照组大鼠组血清瘦素与体重均有相关性(P<0.05),相关系数分别0.84、0.94、0.83;去除体重因素,甲亢组、停药10天组和正常对照组相比,血清瘦素(分别为2.04±0.21ng/ml、2.05±0.24ng/ml、2.14±0.46ng/ml)水平无明显差别(P>0.05),而甲低组血清瘦素(0.68±0.07ng/ml)水平显著低于停药10天组(1.98±0.11ng/ml)和正常对照组(P<0.05)。结论:甲状腺素对血清瘦素的分泌起一定的促进作用。
Objective: To investigate the effect of thyroid hormones on serum leptin in rats with hypothyroidism and hyperthyroidism. Methods: The hypothyroidism and hyperthyroidism were induced in rats by methimazole and euthyrox, and the levels of serum leptin, T_3, T_4, TSH and body weight . Results: Serum leptin and body weight were significantly correlated with hypothyroidism, hyperthyroidism and normal control group (P <0.05), and the correlation coefficients were 0.84, 0.94 and 0.83 respectively. Body mass index, hyperthyroidism group, Serum leptin (2.04 ± 0.21ng / ml, 2.05 ± 0.24ng / ml, 2.14 ± 0.46ng / ml respectively) showed no significant difference compared with the normal control group (P> 0.05) (0.68 ± 0.07ng / ml) was significantly lower than that of the 10-day withdrawal group (1.98 ± 0.11ng / ml) and the normal control group (P <0.05). Conclusion: Thyroxine can promote the secretion of serum leptin.