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假肥大型肌营养不良(DMD)为一致死性疾病,影响儿童,出现近端肌肉力弱,萎缩,腓肠肌肥大,合并心脏受累,关节挛缩,常于25岁前死亡。本病系性连锁遗传,发病率自1;3,067至1:7,689,即每150万人口有324名,危害程度严重,缺乏特效治疗,对家庭社会造成严重问题,因此发现基因携带者,控制男性儿童的生育是控制本病的关键。近年来这方面已作了大量工作,现综述如下。
Duchenne muscular dystrophy (DMD) is a one-of-a-kind fatal disease that affects children with proximal muscular weakness, atrophy, gastrocnemius hypertrophy, combined heart involvement, and joint contracture, often before the age of 25 years. The genetic linkage of the disease, the incidence rate from 1; 3,067 to 1: 7,689, that is, there are 324 per 1.5 million population, the degree of serious harm, the lack of special treatment, causing serious problems for family society, so find gene carriers, control of men Children’s birth control is the key to this disease. In recent years, a great deal of work has been done in this regard. The following is a summary of the work.