论文部分内容阅读
改变海蒽酮(hycanthone)结构而合成的新化合物8-氯-5-羟基-甲基-苯并硫吡喃吲唑N-oxide(IA-4 N-oxide)具有很好的抗血吸虫作用,且无海蒽酮引起的高度突变性和毒性的缺点,对感染血吸虫的小鼠的治疗指数较海蒽酮大12倍,而沙门氏菌属的变活性仅为海蒽酮的1.5%。本文报道新化合物IA-4 N-oxide抗猕猴体内曼氏血吸虫的效果。实验方法:共用体重为3.4～5.5公斤的健康成年猕猴10只,每猴经腹部皮肤感染波多黎各株曼氏血吸虫尾蚴400±50条后分别饲养。将10猴分为5组,每组2猴。分组
The new compound 8-chloro-5-hydroxy-methyl-benzothiopyran-4-oxide (IA-4N-oxide) synthesized by changing the structure of hycanthone has good anti-schistosome effect, There is no high-mutation and toxicity caused by anthrone. The therapeutic index of mice infected with schistosome is 12 times larger than that of sea-anthrone, while the activity of Salmonella is only 1.5% of that of sea-anthrone. This article reports the effect of the new compound IA-4 N-oxide on Schistosoma mansoni. Experimental methods: 10 healthy macaques with a body weight of 3.4-5.5 kg were used. Each monkey was infected with 400 ± 50 S. cercariae Schistosoma mansoni cercaria after abdomen skin infection. Ten monkeys were divided into 5 groups of 2 monkeys. Grouping