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目的 研究从中药桑枝中提取的α 葡萄糖苷酶抑制剂 ,对四氧嘧啶大鼠的高血糖综合症及其糖尿病并发症的实验治疗作用。方法 给四氧嘧啶高血糖大鼠连续口服桑枝水提物 (SZ) 15d ,观察其对高血糖综合症、血脂及糖尿病肾病的影响。结果 连续口服桑枝水提物的四氧嘧啶高血糖大鼠 ,其食和水摄取量、空腹和非禁食血糖、血果糖氨及尿糖等高血糖综合症指标均明显降低 ,血脂得到调节 ,糖尿病肾病得到改善。结论 SZ可能对糖尿病及其并发症有一定的治疗作用
Objective To study the experimental therapeutic effect of α-glucosidase inhibitors extracted from Chinese mulberry branches on hyperglycemic syndrome and diabetic complications in alloxan rats. METHODS: Allergic rats were given oral water extract (SZ) for 15 days to observe its effect on hyperglycemia syndrome, blood lipid and diabetic nephropathy. RESULTS: Alloxan hyperglycemic rats receiving oral water extract of mulberry twigs had significantly lower index of hyperglycemic syndrome such as food and water intake, fasting and non-fasting blood glucose, blood glucose ammonia and urine glucose, and blood lipids were adjusted. Diabetic nephropathy has improved. Conclusion SZ may have a certain therapeutic effect on diabetes and its complications