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采用放射免疫法检测33例消化道癌患者SOD含量。结果表明:肿瘤组SOD含量明显低于正常对照组(t=4.69,P<0.001),且低分化癌组SOD含量明显低于高分化癌组(P<0.01),转移组其含量明显低于未转移组(P<0.001)。8例患者癌灶切除后SOD含量明显升高。提示SOD含量检测可作为肿瘤患者病情监测、预后判断、疗效观察的有效指标之一,同时对消化道癌手术切除可能性的术前估价有一定意义。
Radioimmunoassay was used to detect SOD in 33 patients with gastrointestinal cancer. The results showed that the SOD content in the tumor group was significantly lower than that in the normal control group (t=4.69, P<0.001), and the SOD content in the poorly differentiated cancer group was significantly lower than that in the well-differentiated cancer group (P<0.01), and the content in the metastatic group was significantly lower than that in the normal group. The non-metastatic group (P<0.001). In 8 patients, the SOD content increased significantly after resection of the foci. It is suggested that the detection of SOD content can be used as one of the effective indicators for monitoring the disease condition, evaluating the prognosis and observing the curative effect of cancer patients. At the same time, it has a certain significance for the preoperative evaluation of the possibility of surgical resection of digestive tract cancer.