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目的 :探讨肺癌患者血浆D -二聚体水平与化疗疗效的关系。方法 :采用胶体金方法测定 35例肺癌患者化疗前后血浆D -二聚体的含量。结果 :肺癌患者化疗前血浆D -二聚体水平显著高于正常人 (P <0 0 0 1) ,化疗后有效组 (CR +PR)D -二聚体含量显著低于化疗前 (P <0 0 0 1) ,化疗后稳定组D -二聚体含量与化疗前相比 ,差异无显著性 (P <0 0 5) ,化疗后进展组D -二聚体含量明显高于化疗前 (P <0 0 0 1)。结论 :血浆D -二聚体的水平高低可作为肺癌判断预后、观察疗效的一个指标
Objective: To investigate the relationship between plasma D-dimer levels and the efficacy of chemotherapy in patients with lung cancer. Methods: The plasma D-dimer content in 35 patients with lung cancer before and after chemotherapy was measured by colloidal gold method. Results: Plasma D-dimer levels in patients with lung cancer before chemotherapy were significantly higher than those in normal controls (P <0 01), and after chemotherapy, D-dimer levels in the effective group (CR + PR) were significantly lower than before chemotherapy (P < 0 0 0 1) After chemotherapy, the D-dimer content in the stable group was not significantly different from that before chemotherapy (P < 0.05), and the D-dimer content in the progression group after chemotherapy was significantly higher than before chemotherapy ( P < 0 0 0 1). Conclusion: The level of plasma D-dimer can be used as an index to judge the prognosis and observe the curative effect of lung cancer.