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链毒素(下称SM)的副作用主要有头晕、耳鸣、耳聋等,为防止其副作用的发生,常通过监测血药浓度使其控制在治疗浓度范围内.SM的血药浓度测定法比较SM的血药浓度测定法有两种,一是微生物法,其二是荧光偏振光免疫测定法,两法的相关性良好.微生物法设备简单,但操作费时(培养时间约18h),与利福平、异烟肼联用时,可使其测定值偏高.荧光偏振光免疫法测定操作时间短(约10min),且几乎不受联用药物(利福平和异烟肼)的影响.
Chain toxins (hereinafter referred to as SM) side effects are mainly dizziness, tinnitus, deafness, etc., in order to prevent the occurrence of side effects, often by monitoring the concentration of plasma to control within the therapeutic concentration range.SM plasma concentration determination method SM There are two methods for the determination of plasma concentration, one is microbiological method, the other is fluorescence polarization immunoassay, the correlation between the two methods is good.The microbiological method is simple, but the operation time-consuming (culture time is about 18h) , Isoniazid can be combined with its high measured value.Phosphorescence polarization immunoassay for short operation time (about 10min), and almost no combination of drugs (rifampicin and isoniazid) influence.