论文部分内容阅读
在大鼠离体工作心脏上，ＡＴＰ敏感性Ｋ＋通道开放剂吡那地尔（ＰＩＮ）１～１０μｍｏｌ／Ｌ可加快心率，１０μｍｏｌ／Ｌ产生负性肌力作用，使主动脉射量略有下降，但不影响冠脉流量。０．１μｍｏｌ／Ｌ二氢吡啶类钙拮抗剂硝苯啶（ＮＩＦ）可减慢心率，降低主动脉射量，１．０μｍｏｌ／ＬＮＩＦ有明显的负性肌力及负性频率作用，主动脉射量显著下降，冠脉流量变化不明显。提示ＰＩＮ及ＮＩＦ均可直接作用于心脏，但二者的作用性质及作用强度不同，ＰＩＮ有较轻的正性频率和负性肌力作用，ＮＩＦ有明显的负性频率和负性肌力作用
In isolated rat hearts, ATP sensitive K + channel opener pinacidil (PIN) 1 ~ 10μmol / L can speed up the heart rate, 10μmol / L produce negative inotropic effect, the aortic jet slightly decreased , But does not affect the coronary flow. 0.1μmol / L dihydropyridine calcium antagonist nifedipine (NIF) can slow down the heart rate, reduce the aortic injection, 1.0μmol / LNIF significant negative and negative frequency of negative effects, aortic shoot Volume decreased significantly, coronary flow changes were not obvious. Tip PIN and NIF can be directly applied to the heart, but the role of the nature and intensity of the two different, PIN has a mild positive frequency and negative muscle strength, NIF significant negative frequency and negative muscle strength