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表达外源抗原的重组卡介苗（rBCG）能诱导很强的细胞和体液免疫应答。由于许多人都曾接种过卡介苗（BCG）,这可能会影响以后接种rBCG疫苗的免疫原性。 作者以未免疫的BALB/c鼠为对照,用两种分别表达β半乳糖苷酶（LacZ）和1型人类免疫缺陷症病毒（HIV-1）Nef抗原的rBCG,研究BCG初免对rBCG诱导的免疫
Recombinant BCG expressing foreign antigen can induce strong cellular and humoral immune response Since many people have been vaccinated with BCG, this may affect the immunogenicity of subsequent rBCG vaccination. The authors investigated the induction of rBCG induction by BCG priming with two non-immune BALB / c mice as control, using two rBCGs expressing the β-galactosidase (LacZ) and the Nef antigen of human immunodeficiency virus type 1 (HIV-1) Immune