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目的:测定胰岛素样生长因子-Ⅰ受体(insulin-like growthfactor-Ⅰreceptor,IGF-ⅠR)在乳腺癌组织中的表达情况,研究其临床意义。方法:应用免疫组织化学法测定78例乳腺癌组织中IGF-ⅠR的表达情况,分析其与发病年龄、肿瘤大小、淋巴结转移状态、ER、PR和HER-2等生物学特征的关系,以及与预后之间的关系。结果:乳腺癌组织中IGF-ⅠR阳性表达率为37.2%(29/78),其中弱阳性(+)20例,中度阳性(++)7例,强阳性(+++)2例。而癌旁组织中均无IGF-ⅠR表达。依据IGF-ⅠR状态将全部病例分为阳性组和阴性组。IGF-ⅠR阳性组患者的ER阳性率显著高于IGF-ⅠR阴性组(89.7%vs63.3%),P=0.01。而IGF-ⅠR与发病年龄、肿瘤直径、淋巴结状态、TNM分期、PR、HER-2及生存率无相关性。结论:IGF-ⅠR在乳腺癌中过表达,并与ER状态相关,可能成为乳腺癌临床诊断的一个重要指标,并对预测预后有一定价值。
Objective: To determine the expression of insulin-like growth factor-Ⅰ receptor (IGF-ⅠR) in breast cancer and to investigate the clinical significance. Methods: The expression of IGF-ⅠR in 78 cases of breast cancer was detected by immunohistochemistry. The relationship between the expression of IGF-ⅠR and age, tumor size, lymph node metastasis, ER, PR and HER-2 and other biological characteristics were analyzed. The relationship between the prognosis. Results: The positive rate of IGF-ⅠR in breast cancer tissues was 37.2% (29/78). There were 20 cases with weak positive (+), 7 cases with moderate positive (++) and 2 cases with strong positive (+++). There was no IGF-ⅠR expression in adjacent tissues. All cases were divided into positive group and negative group according to IGF-ⅠR status. The positive rate of ER in IGF-IR positive group was significantly higher than that in IGF-IR negative group (89.7% vs63.3%), P = 0.01. There was no correlation between IGF-IR and age of onset, tumor diameter, lymph node status, TNM stage, PR, HER-2 and survival rate. CONCLUSIONS: IGF-IR is overexpressed in breast cancer and correlated with ER status, which may be an important indicator in the clinical diagnosis of breast cancer and has certain value in predicting prognosis.