近二十多年来,药物体内乙酰化和氧化代谢呈现出的多型性,已受到各国药理学家的关注,并开辟了药理遗传研究的新领域。氧化代谢快、慢型的研究近十余年才开始,但它比乙酰化代谢更为重要,对药物的临床合理应用具有重要意义。异喹胍(debrisoquine)是肾上腺素能阻滞剂,口服后在肝内羟化代谢成无药理 In recent twenty years, the in vivo acetylation and metabolism of drugs showed polymorphism, which has attracted the attention of pharmacologists in various countries and opened up new fields of pharmacological genetic research. Oxidative metabolism of fast, slow type of research began more than ten years, but it is more important than the acetylation metabolism, the clinical rational use of drugs is of great significance. Debrisoquine, an adrenergic blocker, is metabolized in the liver to no pharmacology after oral administration