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目的观察米氮平对脑梗死伴发抑郁患者的疗效。方法 60例脑梗死后抑郁的患者,随机分为治疗组和对照组,每组30例。治疗组服用米氮平进行治疗,对照组服用阿米替林进行治疗。采用汉密尔顿抑郁量表(HAMD)以及日常生活能力量表(ADL)对两组患者的抗抑郁效果进行评定。结果与对照组比较,治疗组ADL评分升高,HAMD评分降低,差异有统计学意义(P<0.05);治疗组痊愈15例,显效10例,有效5例,无效0例,总有效率为100.00%;对照组痊愈2例,显效3例,有效5例,无效20例,总有效率为33.33%。两组患者脑梗死后抑郁的疗效相比较,治疗组抗抑郁的疗效明显优于对照组,差异具有统计学意义(P<0.05)。结论米氮平对脑梗死后抑郁具有很好的疗效,在抑郁症状改善的同时,促进患者神经功能和日常生活能力的恢复。
Objective To observe the effect of mirtazapine on patients with cerebral infarction complicated by depression. Methods Sixty patients with depression after cerebral infarction were randomly divided into treatment group and control group, with 30 cases in each group. The treatment group took mirtazapine for treatment, while the control group took amitriptyline for treatment. The antidepressant effects of both groups were assessed using the Hamilton Depression Rating Scale (HAMD) and the Daily Living Fitness Scale (ADL). Results Compared with the control group, ADL score increased and HAMD score decreased in the treatment group (P <0.05). In the treatment group, 15 cases were cured, 10 cases markedly effective, 5 effective and 0 ineffective. The total effective rate was 100.00%. In the control group, 2 cases were cured, 3 cases were markedly effective, 5 cases were effective and 20 cases were ineffective. The total effective rate was 33.33%. Compared with the control group, the curative effect of antidepressant in the treatment group was significantly better than that in the control group (P <0.05). Conclusion Mirtazapine has a good curative effect on depression after cerebral infarction, and at the same time it improves the recovery of neurological function and daily living ability of patients.