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目的 :通过测定前列腺疾病患者血清中胰岛素样生长因子 - I(insulin- like growth factor- I IGF- I)、前列腺特异性抗原 (prostatic specific antigen PSA)和游离前列腺特异性抗原 (free prostatic specific antigen f PSA)的水平 ,探讨其在前列腺疾病的诊断作用。方法 :采用放射免疫分析法 (RIA)和微粒子化学发光法对 4 8例前列腺癌 (prostaticcarcinoma PCa)患者 ,5 0例良性前列腺增生 (benign prostate hyperplasia,BPH)患者和 35例健康男性 (正常对照组 )血清中 IGF- I、PSA和 f PSA进行定量测定并进行比较分析。结果 :前列腺癌患者血清中 IGF- I、PSA、f PSA的水平明显高于 BPH组和正常对照组 (P<0 .0 1) ,IGF- I在前列腺癌的发展过程中有增高趋势 ,但各分期没有统计学意义 (P>0 .0 5 ) ;BPH组与正常对照组之间比较差异无显著性 (P>0 .0 5 ) ,但 IGF- I水平随前列腺体积 (PV)的增加而有所升高。结论 :IGF- I的高低与前列腺增生程度有关 ;IGF- I水平的升高可能增加了前列腺癌的危险性 ,IGF- I有可能作为一个新的 PCa高危人群的预测指标
Objective: To determine the serum levels of insulin-like growth factor-I (IGF-I), prostatic specific antigen (PSA) and free prostatic specific antigen f PSA) levels, to explore its role in the diagnosis of prostate disease. Methods: Forty eight patients with prostatic carcinoma (PCa), 50 benign prostatic hyperplasia (BPH) patients and 35 healthy male controls (normal control group) were studied by radioimmunoassay (RIA) and microparticle chemiluminescence ) Serum IGF-I, PSA and f PSA quantitative determination and comparative analysis. Results: Serum levels of IGF-I, PSA and f PSA in patients with prostate cancer were significantly higher than those in BPH and normal controls (P <0.01). IGF-I tended to increase in the development of prostate cancer The staging was not statistically significant (P> 0.05). There was no significant difference between BPH group and normal control group (P> 0.05), but the level of IGF-I increased with the increase of prostate volume (PV) And has risen. Conclusion: The level of IGF-I is related to the degree of benign prostatic hyperplasia. Elevated IGF-I level may increase the risk of prostate cancer. IGF-I may be used as a new predictor of high risk population of PCa