【摘 要】
：
目的研究灰旱獭感染乙型肝炎病毒(HBV)后的血清学反应.方法实验前普查28只实验灰旱獭对乙肝病毒标志物(HBV M)的血清学变化,选阴性健康旱獭用含HBV DNA的人血清进行皮下、肌
【机 构】
：
新疆维吾尔族自治区人民医院感染科,新疆地方病研究所动物昆虫研究室
论文部分内容阅读
目的研究灰旱獭感染乙型肝炎病毒(HBV)后的血清学反应.方法实验前普查28只实验灰旱獭对乙肝病毒标志物(HBV M)的血清学变化,选阴性健康旱獭用含HBV DNA的人血清进行皮下、肌内和腹腔多点注射(4.96×106 cop/ml×1.33 ml),接种后1～8周(每日)和2～12个月(每1～2个月)观察行为变化,检测HBV M,HBV DNA和ALT/AST.结果攻毒前抗-HBc+率为7.1%(2/28),攻毒后抗-HBc+率为31.8%,HBsAg+率为4.3%,HBV DNA+率为16.6%,ALT一周后开始升高,2～3个月达高峰(高于正常2～9倍)并持续6个月,AST低平曲线高峰迟发一个月.全程死亡7只(25%),攻毒后死亡1只(1/7).结论攻毒后HBV和ALT/AST的变化提示HBV感染后能产生肝细胞炎症反应.
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