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目的建立并比较两种链脲佐菌素实验性2型糖尿病大鼠模型。方法采用一次性大剂量向大鼠腹腔内注射链脲佐菌素和先饲喂高糖高脂饲料,再小剂量腹腔注射链脲佐菌素两种方法建立动物模型。结果两个模型组血糖升高,对胰岛素敏感下降,从生化指标和形态学上证实建模成功。结论两个模型组建模成功,高血糖明显、成功率高,建模周期及糖尿病发生过程略有区别,可根据实验要求选用。
Objective To establish and compare two streptozotocin experimental type 2 diabetic rat models. Methods A one-time high-dose injection of streptozotocin into the abdominal cavity of rats and high-fat and high-fat diet first, and then a small dose of intraperitoneal injection of streptozotocin two animal models. Results The blood glucose of the two model groups was increased, and insulin sensitivity was decreased. The biochemical indexes and morphology confirmed the successful modeling. Conclusions The two model groups have successful modeling, obvious hyperglycemia, high success rate, slight difference between the modeling period and the occurrence of diabetes, which can be selected according to the experimental requirements.